Antibodies to elastin peptides in sera of Belgian Draught horses with chronic progressive lymphoedema
Identifieur interne : 007667 ( Main/Exploration ); précédent : 007666; suivant : 007668Antibodies to elastin peptides in sera of Belgian Draught horses with chronic progressive lymphoedema
Auteurs : L. Van Brantegem [Belgique] ; H. E. V. De Cock [Belgique] ; V. K. Affolter [États-Unis] ; L. Duchateau [Belgique] ; M. K. Hoogewijs [Belgique] ; J. Govaere [Belgique] ; G. L. Ferraro [États-Unis] ; R. Ducatelle [Belgique]Source :
- Equine Veterinary Journal [ 0425-1644 ] ; 2007-09.
Descripteurs français
- KwdFr :
- Animaux, Autoanticorps (sang), Bronchopneumopathies obstructives (diagnostic), Bronchopneumopathies obstructives (médecine vétérinaire), Bronchopneumopathies obstructives (sang), Desmosine (métabolisme), Diagnostic différentiel, Equus caballus, Femelle, Indice de gravité médicale, Lymphoedème (anatomopathologie), Lymphoedème (diagnostic), Lymphoedème (médecine vétérinaire), Lymphoedème (sang), Maladie chronique, Maladies des chevaux (anatomopathologie), Maladies des chevaux (diagnostic), Maladies des chevaux (sang), Mâle, Peau (anatomopathologie), Peptides (immunologie), Peptides (métabolisme), Peptides (sang), Sensibilité et spécificité, Sélection, Test ELISA (), Test ELISA (médecine vétérinaire), Test ELISA (normes), Valeurs de référence, Vieillissement (métabolisme), Vieillissement (physiologie), Élastine (immunologie), Élastine (métabolisme), Élastine (sang), Évolution de la maladie.
- MESH :
- anatomopathologie : Lymphoedème, Maladies des chevaux, Peau.
- diagnostic : Bronchopneumopathies obstructives, Lymphoedème, Maladies des chevaux.
- immunologie : Peptides, Élastine.
- médecine vétérinaire : Bronchopneumopathies obstructives, Lymphoedème, Test ELISA.
- métabolisme : Desmosine, Peptides, Vieillissement, Élastine.
- normes : Test ELISA.
- physiologie : Vieillissement.
- sang : Autoanticorps, Bronchopneumopathies obstructives, Lymphoedème, Maladies des chevaux, Peptides, Élastine.
- Animaux, Diagnostic différentiel, Equus caballus, Femelle, Indice de gravité médicale, Maladie chronique, Mâle, Sensibilité et spécificité, Sélection, Test ELISA, Valeurs de référence, Évolution de la maladie.
English descriptors
- KwdEn :
- Aging (metabolism), Aging (physiology), Animals, Autoantibodies (blood), Breeding, Chronic Disease, Desmosine (metabolism), Diagnosis, Differential, Disease Progression, Elastin (blood), Elastin (immunology), Elastin (metabolism), Enzyme-Linked Immunosorbent Assay (methods), Enzyme-Linked Immunosorbent Assay (standards), Enzyme-Linked Immunosorbent Assay (veterinary), Female, Horse Diseases (blood), Horse Diseases (diagnosis), Horse Diseases (pathology), Horses, Lung Diseases, Obstructive (blood), Lung Diseases, Obstructive (diagnosis), Lung Diseases, Obstructive (veterinary), Lymphedema (blood), Lymphedema (diagnosis), Lymphedema (pathology), Lymphedema (veterinary), Male, Peptides (blood), Peptides (immunology), Peptides (metabolism), Reference Values, Sensitivity and Specificity, Severity of Illness Index, Skin (pathology).
- MESH :
- chemical , blood : Autoantibodies, Elastin, Peptides.
- chemical , immunology : Elastin, Peptides.
- blood : Horse Diseases, Lung Diseases, Obstructive, Lymphedema.
- diagnosis : Horse Diseases, Lung Diseases, Obstructive, Lymphedema.
- metabolism : Aging, Desmosine, Elastin, Peptides.
- methods : Enzyme-Linked Immunosorbent Assay.
- pathology : Horse Diseases, Lymphedema, Skin.
- physiology : Aging.
- standards : Enzyme-Linked Immunosorbent Assay.
- veterinary : Enzyme-Linked Immunosorbent Assay, Lung Diseases, Obstructive, Lymphedema.
- Animals, Breeding, Chronic Disease, Diagnosis, Differential, Disease Progression, Female, Horses, Male, Reference Values, Sensitivity and Specificity, Severity of Illness Index.
Abstract
Reasons for performing study: Chronic progressive lymphoedema (CPL) is a recently recognised disease of the lymphatic system characterised by lesions in the skin of the lower legs in several draught horse breeds, including the Belgian Draught hourse. Clinical signs slowly progress and result in severe disfigurement of the limbs. Ideally, supportive treatment should be started early in the disease process. However early diagnosis and monitoring progression of CPL is still a challenge. Hypothesis: Elastin changes, characterised by morphological alterations as well as increased desmosine levels, in the skin of the distal limbs of horses affected with CPL are probably associated with a marked release of elastin degradation products, which elicit production of circulating anti‐elastin antibodies (AEAbs) in the serum. An enzyme‐linked immunosorbent assay (ELISA) for detection of serum AEAbs may document elastin breakdown. Methods: An ELISA technique was used to evaluate levels of AEAbs in sera of 97 affected Belgian Draught horses that were clinically healthy except for possible skin lesions, associated with CPL in their distal limbs. The horses were divided into 5 groups according to the severity of these skin lesions: normal horses (Group 1, n = 36), horses with mild lesions (Group 2, n = 43), horses with moderate lesions (Group 3, n = 8), horses with severe lesions (Group 4, n = 10) and, as a control, healthy Warmblood horses, unaffected by the disease (Group 5, n = 83). Results: Horses with clinical signs of CPL had significantly higher AEAb levels compared to clinically normal Belgian Draught horses and to healthy Warmblood horses. These levels correlated with severity of lesions. Conclusions: CPL in draught horses is associated with an increase of serum AEAbs. Potential relevance: Evaluation of serum levels of AEAbs by ELISA might be a useful diagnostic aid for CPL. Pathological degradation of elastic fibres, resulting in deficient support of the distal lymphatics, is proposed as a contributing factor for CPL in Belgian Draught horses.
Url:
- https://api.istex.fr/document/F54C8E2C7953F33AE3DB04697FA8E1120A4D7AB5/fulltext/pdf
- https://api.istex.fr/document/B4FE73EC0690AE58E735FD4ACEE2EFD85E832101/fulltext/pdf
DOI: 10.2746/042516407X205888
Affiliations:
- Belgique, États-Unis
- Province d'Anvers, Province de Flandre-Orientale, Région flamande
- Anvers, Gand
- Université d'Anvers, Université de Gand
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Le document en format XML
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Ducatelle</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Pathology, Department of Veterinary Medicine, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Pathology, Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Equine Veterinary Journal</title><title level="j" type="alt">EQUINE VETERINARY JNL</title><idno type="ISSN">0425-1644</idno><idno type="eISSN">2042-3306</idno><imprint><biblScope unit="vol">39</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="418">418</biblScope><biblScope unit="page" to="421">421</biblScope><biblScope unit="page-count">4</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2007-09">2007-09</date></imprint><idno type="ISSN">0425-1644</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0425-1644</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (metabolism)</term><term>Aging (physiology)</term><term>Animals</term><term>Autoantibodies (blood)</term><term>Breeding</term><term>Chronic Disease</term><term>Desmosine (metabolism)</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Elastin (blood)</term><term>Elastin (immunology)</term><term>Elastin (metabolism)</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Enzyme-Linked Immunosorbent Assay (standards)</term><term>Enzyme-Linked Immunosorbent Assay (veterinary)</term><term>Female</term><term>Horse Diseases (blood)</term><term>Horse Diseases (diagnosis)</term><term>Horse Diseases (pathology)</term><term>Horses</term><term>Lung Diseases, Obstructive (blood)</term><term>Lung Diseases, Obstructive (diagnosis)</term><term>Lung Diseases, Obstructive (veterinary)</term><term>Lymphedema (blood)</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (pathology)</term><term>Lymphedema (veterinary)</term><term>Male</term><term>Peptides (blood)</term><term>Peptides (immunology)</term><term>Peptides (metabolism)</term><term>Reference Values</term><term>Sensitivity and Specificity</term><term>Severity of Illness Index</term><term>Skin (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Autoanticorps (sang)</term><term>Bronchopneumopathies obstructives (diagnostic)</term><term>Bronchopneumopathies obstructives (médecine vétérinaire)</term><term>Bronchopneumopathies obstructives (sang)</term><term>Desmosine (métabolisme)</term><term>Diagnostic différentiel</term><term>Equus caballus</term><term>Femelle</term><term>Indice de gravité médicale</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (diagnostic)</term><term>Lymphoedème (médecine vétérinaire)</term><term>Lymphoedème (sang)</term><term>Maladie chronique</term><term>Maladies des chevaux (anatomopathologie)</term><term>Maladies des chevaux (diagnostic)</term><term>Maladies des chevaux (sang)</term><term>Mâle</term><term>Peau (anatomopathologie)</term><term>Peptides (immunologie)</term><term>Peptides (métabolisme)</term><term>Peptides (sang)</term><term>Sensibilité et spécificité</term><term>Sélection</term><term>Test ELISA ()</term><term>Test ELISA (médecine vétérinaire)</term><term>Test ELISA (normes)</term><term>Valeurs de référence</term><term>Vieillissement (métabolisme)</term><term>Vieillissement (physiologie)</term><term>Élastine (immunologie)</term><term>Élastine (métabolisme)</term><term>Élastine (sang)</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term><term>Elastin</term><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Elastin</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Maladies des chevaux</term><term>Peau</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Horse Diseases</term><term>Lung Diseases, Obstructive</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Horse Diseases</term><term>Lung Diseases, Obstructive</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Bronchopneumopathies obstructives</term><term>Lymphoedème</term><term>Maladies des chevaux</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Peptides</term><term>Élastine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aging</term><term>Desmosine</term><term>Elastin</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Bronchopneumopathies obstructives</term><term>Lymphoedème</term><term>Test ELISA</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Desmosine</term><term>Peptides</term><term>Vieillissement</term><term>Élastine</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Test ELISA</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Horse Diseases</term><term>Lymphedema</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Autoanticorps</term><term>Bronchopneumopathies obstructives</term><term>Lymphoedème</term><term>Maladies des chevaux</term><term>Peptides</term><term>Élastine</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term><term>Lung Diseases, Obstructive</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Breeding</term><term>Chronic Disease</term><term>Diagnosis, Differential</term><term>Disease Progression</term><term>Female</term><term>Horses</term><term>Male</term><term>Reference Values</term><term>Sensitivity and Specificity</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Diagnostic différentiel</term><term>Equus caballus</term><term>Femelle</term><term>Indice de gravité médicale</term><term>Maladie chronique</term><term>Mâle</term><term>Sensibilité et spécificité</term><term>Sélection</term><term>Test ELISA</term><term>Valeurs de référence</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reasons for performing study: Chronic progressive lymphoedema (CPL) is a recently recognised disease of the lymphatic system characterised by lesions in the skin of the lower legs in several draught horse breeds, including the Belgian Draught hourse. Clinical signs slowly progress and result in severe disfigurement of the limbs. Ideally, supportive treatment should be started early in the disease process. However early diagnosis and monitoring progression of CPL is still a challenge. Hypothesis: Elastin changes, characterised by morphological alterations as well as increased desmosine levels, in the skin of the distal limbs of horses affected with CPL are probably associated with a marked release of elastin degradation products, which elicit production of circulating anti‐elastin antibodies (AEAbs) in the serum. An enzyme‐linked immunosorbent assay (ELISA) for detection of serum AEAbs may document elastin breakdown. Methods: An ELISA technique was used to evaluate levels of AEAbs in sera of 97 affected Belgian Draught horses that were clinically healthy except for possible skin lesions, associated with CPL in their distal limbs. The horses were divided into 5 groups according to the severity of these skin lesions: normal horses (Group 1, n = 36), horses with mild lesions (Group 2, n = 43), horses with moderate lesions (Group 3, n = 8), horses with severe lesions (Group 4, n = 10) and, as a control, healthy Warmblood horses, unaffected by the disease (Group 5, n = 83). Results: Horses with clinical signs of CPL had significantly higher AEAb levels compared to clinically normal Belgian Draught horses and to healthy Warmblood horses. These levels correlated with severity of lesions. Conclusions: CPL in draught horses is associated with an increase of serum AEAbs. Potential relevance: Evaluation of serum levels of AEAbs by ELISA might be a useful diagnostic aid for CPL. Pathological degradation of elastic fibres, resulting in deficient support of the distal lymphatics, is proposed as a contributing factor for CPL in Belgian Draught horses.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>États-Unis</li></country><region><li>Province d'Anvers</li><li>Province de Flandre-Orientale</li><li>Région flamande</li></region><settlement><li>Anvers</li><li>Gand</li></settlement><orgName><li>Université d'Anvers</li><li>Université de Gand</li></orgName></list><tree><country name="Belgique"><region name="Région flamande"><name sortKey="Van Brantegem, L" sort="Van Brantegem, L" uniqKey="Van Brantegem L" first="L." last="Van Brantegem">L. Van Brantegem</name></region><name sortKey="De Cock, H E V" sort="De Cock, H E V" uniqKey="De Cock H" first="H. E. V." last="De Cock">H. E. V. De Cock</name><name sortKey="Ducatelle, R" sort="Ducatelle, R" uniqKey="Ducatelle R" first="R." last="Ducatelle">R. Ducatelle</name><name sortKey="Ducatelle, R" sort="Ducatelle, R" uniqKey="Ducatelle R" first="R." last="Ducatelle">R. Ducatelle</name><name sortKey="Duchateau, L" sort="Duchateau, L" uniqKey="Duchateau L" first="L." last="Duchateau">L. Duchateau</name><name sortKey="Govaere, J" sort="Govaere, J" uniqKey="Govaere J" first="J." last="Govaere">J. Govaere</name><name sortKey="Hoogewijs, M K" sort="Hoogewijs, M K" uniqKey="Hoogewijs M" first="M. K." last="Hoogewijs">M. K. Hoogewijs</name><name sortKey="Van Brantegem, L" sort="Van Brantegem, L" uniqKey="Van Brantegem L" first="L." last="Van Brantegem">L. Van Brantegem</name></country><country name="États-Unis"><noRegion><name sortKey="Affolter, V K" sort="Affolter, V K" uniqKey="Affolter V" first="V. K." last="Affolter">V. K. Affolter</name></noRegion><name sortKey="Ferraro, G L" sort="Ferraro, G L" uniqKey="Ferraro G" first="G. L." last="Ferraro">G. L. 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